Zopiclone (Imovane) is indicated for the short-term remedy and symptomatic reduction of insomnia characterised by difficulty in falling asleep, frequent nocturnal awakenings and/or early morning awakenings.
Treatment with zopiclone should normally not exceed 7-10 consecutive days. Use for greater than 2-3 consecutive weeks requires full re-evaluation of the affected person. Prescriptions for zopiclone must be written for short-term use (7-10 days) and it should not be prescribed in quantities exceeding a 1-month supply.
The use of hypnotics must be restricted for insomnia where disturbed sleep results in impaired daytime functioning.
Dosage and administration:
Imovane should solely be taken when you are ready to get a full night’s sleep (7 to 8 hours) earlier than you have to be active once more.
The standard adult dose of zopiclone is one tablet simply earlier than you go to mattress.
This treatment should be taken in a single intake and not readministered throughout the same evening.
If you would possibly be over sixty five years of age the dose is half a tablet taken just before you go to bed.
If you have a liver or kidney problem, the usual really helpful dose is half a tablet taken just before you go to mattress.
Signs and symptoms:
Overdose by zopiclone drugs is often manifested by varying degrees of central nervous system depression starting from drowsiness to coma in accordance with the amount ingested. In gentle instances, symptoms embody drowsiness, confusion, and lethargy; in additional severe instances, symptoms might include ataxia, hypotonia, hypotension, methaemoglobinaemia, respiratory depression, and coma. Overdose should not be life threatening until mixed with different CNS depressants, together with alcohol. Other threat factors, such because the presence of concomitant illness and the debilitated state of the patient, may contribute to the severity of symptoms and really rarely can end result in deadly outcome.
In voluntary or unintentional cases of zopiclone overdosage involving doses up to 340 mg, the principal effects reported were extended sleep, drowsiness, lethargy and ataxia.
Symptomatic and supportive therapy in enough clinical setting is recommended, consideration must be paid to respiratory and cardiovascular capabilities. Gastric lavage or activated charcoal is just useful when performed quickly after ingestion.
Hemodialysis is of no worth due to the giant quantity of distribution of zopiclone. Flumazenil could also be a useful antidote; however, flumazenil administration might contribute to the looks of neurological symptoms (agitation, anxiousness, convulsionsand emotional lability). Intravenous fluids should be administered as needed.